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https://hdl.handle.net/2440/113562
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Type: | Journal article |
Title: | Improvement of major depression is associated with increased erythrocyte DHA |
Author: | Meyer, B.J. Grenyer, B.F.S. Crowe, T. Owen, A.J. Grigonis-Deane, E.M. Howe, P.R.C. |
Citation: | Lipids, 2013; 48(9):863-868 |
Publisher: | Wiley |
Issue Date: | 2013 |
ISSN: | 0024-4201 1558-9307 |
Statement of Responsibility: | Barbara J. Meyer, Brin F. S. Grenyer, Trevor Crowe, Alice J. Owen, Elizabeth M. Grigonis-Deane, Peter R. C. Howe |
Abstract: | The aim of this study was to determine if changes in omega-3 polyunsaturated fatty acid status following tuna oil supplementation correlated with changes in scores of depression. A total of 95 volunteers receiving treatment for major depression were randomised to consume 8 × 1 g capsules per day of HiDHA (2 g DHA, 0.6 g EPA and 10 mg Vitamin E) or olive oil (placebo) for 16 weeks, whilst undergoing weekly counseling sessions by trained clinical psychologists using a standard empirically validated psychotherapy. Depression status was assessed using the 17 item Hamilton rating scale for depression and the Beck Depression Inventory by a psychodiagnostician who was blind to the treatment. Blood was taken at baseline and 16 weeks (n = 48) for measurement of erythrocyte fatty acids. With HiDHA supplementation, erythrocyte DHA content rose from 4.1 ± 0.2 to 7.9 ± 0.4 % (mean ± SEM, p < 0.001) of total fatty acids but did not change (4.0 ± 0.2 to 4.1 ± 0.2 %) in the olive oil group. The mean changes in scores of depression did not differ significantly between the two groups (-12.2 ± 2.1 for tuna oil and -14.4 ± 2.3 for olive oil). However, analysis of covariance showed that in the fish oil group there was a significant correlation (r = -0.51) between the change in erythrocyte DHA and the change in scores of depression (p < 0.05). Further study of the relationship between DHA and depression is warranted. |
Keywords: | n-3 Fatty acids; Nutrition |
Description: | Published online: 4 June 2013 |
Rights: | © AOCS 2013 |
DOI: | 10.1007/s11745-013-3801-7 |
Published version: | http://dx.doi.org/10.1007/s11745-013-3801-7 |
Appears in Collections: | Aurora harvest 3 Molecular and Biomedical Science publications |
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