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https://hdl.handle.net/2440/35547
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Type: | Journal article |
Title: | ARDent about acetylation and deacetylation in hypoxia signalling |
Author: | Bilton, Rebecca Louise Trottier, Eric Pouyssegur, Jacques Brahimi-Horn, M. Christiane |
Citation: | Trends in Cell Biology, 2006; 16(12):616-621 |
Publisher: | Elsevier |
Issue Date: | 2006 |
ISSN: | 0962-8924 |
School/Discipline: | School of Molecular and Biomedical Science |
Organisation: | Centre for the Molecular Genetics of Development |
Statement of Responsibility: | Rebecca Bilton, Eric Trottier, Jacques Pouysségur and M. Christiane Brahimi-Horn |
Abstract: | Given the key role that the α subunit of the αβ heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1) has in tumourigenesis, and in particular in angiogenesis, a full understanding of its regulation is crucial to the development of cancer therapeutics. Posttranslational acetylation and deacetylation of this subunit by an acetyltransferase called Arrest-defective-1 (ARD1) and by different histone deacetylases (HDACs), respectively, has been suggested as a mechanism. However, conflicting data bring into question the foundations of this mechanism and at present it is not clear what the precise role of these proteins is with respect to HIF. Nonetheless, the observation that small-molecule inhibitors of HDACs have anti-angiogenic activity suggests that acetylation and deacetylation of HIF or HIF modifiers represents a potential target in cancer therapy. |
Description: | Copyright © 2006 Elsevier Ltd All rights reserved. |
DOI: | 10.1016/j.tcb.2006.10.002 |
Description (link): | http://www.sciencedirect.com/science/journal/09628924 |
Appears in Collections: | Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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