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https://hdl.handle.net/2440/38758
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Type: | Journal article |
Title: | Decreased interleukin-10 in tracheal aspirates from preterm infants developing chronic lung disease. |
Author: | Oei, J. Lui, K. Wang, He Henry, Richard L. |
Citation: | Acta Paediatrica, 2002; 91 (11):1194-1199 |
Publisher: | Taylor and Francis |
Issue Date: | 2002 |
ISSN: | 0803-5253 |
School/Discipline: | School of Population Health and Clinical Practice : Public Health |
Statement of Responsibility: | J. Oei, K. Lui, H. Wang and R. Henry |
Abstract: | The inability to balance pulmonary injury with healing may predispose preterm infants to chronic lung disease (CLD). It is postulated that the production of interleukin (IL)-10, an anti-inflammatory cytokine, is gestationally influenced and that CLD-prone infants may have a reduced ability to produce IL-10. Methods: Tracheal fluid (TF) was collected at least twice weekly from 48 mechanically ventilated infants within the first 7 d of life while intubated. Results: A total of 87 TF specimens were obtained. None of the 11 CLD infants (24-31 wk of gestation) had TF IL-10 levels above 4 pg/ml (0/20 TF specimens), while 14 (70%) of the 20 non-CLD preterm infants (27-36 wk of gestation) had IL-10 levels above 5 pg/ml in one or more of their TF specimens (18/48 TF specimens, p < 0.001). Only the 5 term infants who were ventilated for severe lung disease had raised IL-10 levels (17 infants, 5/19 TF specimens). IL-10 levels, if detected, (range 6938 pg/ml) tended to be higher with increasing gestation (Spearman's rho coefficient = 0.43; p = 0.003). TF IL-10 detection was not associated with hyaline membrane disease, antenatal steroids or influenced by TF sample volume. Overall IL-8 levels were wide ranging but towards the end of week 1 the levels were significantly higher in CLD infants (CLD: median 34 184 ng/ml, preterm non-CLD: median 699 ng/ml, p < 0.001, term: 2961 ng/ml, p = 0.028). Conclusion: A gestationally influenced low IL-10 may predispose preterm infants to persistent pulmonary inflammation of CLD. |
Keywords: | Chronic lung disease; IL-8; IL-10; neonates |
Description: | © Taylor & Francis |
DOI: | 10.1111/j.1651-2227.2002.tb00128.x |
Published version: | http://www3.interscience.wiley.com/journal/119926692/abstract |
Appears in Collections: | Public Health publications |
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