Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/4028
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Type: Journal article
Title: Calcium supplementation in nulliparous women for the prevention of pregnancy-induced hypertension, preeclampsia and preterm birth: an Australian randomised trial
Author: Crowther, C.
Hiller, J.
Pridmore, B.
Bryce, R.
Duggan, P.
Hague, W.
Robinson, J.
Citation: Australian and New Zealand Journal of Obstetrics and Gynaecology, 1999; 39(1):Dec-18
Publisher: AUSTRALIAN NZ J OBSTET GYNAEC
Issue Date: 1999
ISSN: 0004-8666
1479-828X
Statement of
Responsibility: 
Caroline A. Crowther, Janet E. Hiller, Brian Pridmore, Robert Bryce, Paul Duggan, William M. Hague, Jeffrey S. Robinson
Abstract: A multicentre, randomized controlled double-blind trial in 5 maternity hospitals in Australia assessed the effect of a daily supplement of calcium (1.8g oral calcium or an oral placebo) taken daily until delivery, from less than 24 weeks' gestation, on the frequency of pregnancy-induced hypertension, preeclampsia and preterm birth (< 37 weeks' gestation) in 456 nulliparas with a singleton pregnancy. Treatment with calcium reduced the risk of preeclampsia (relative risk 0.44 [95% CI, 0.21-0.90], p = 0.02) and the risk of preterm birth (relative risk 0.44 [95% CI, 0.21-0.90], p = 0.02). No significant differences were seen between the 2 groups in the frequency of pregnancy-induced hypertension, although the study only had statistical power to detect large differences in this outcome. An updated systematic review of the 9 randomized trials of calcium supplementation in pregnancy shows a significant reduction in the risk of hypertension and preeclampsia although no effect on preterm birth. Calcium supplementation during pregnancy reduced the risk of preeclampsia and preterm birth in this nulliparous population. The available evidence for systematic review of all the randomized trials of calcium supplementation shows benefit in reducing the risk of hypertension and preeclampsia.
Keywords: Humans; Pre-Eclampsia; Pregnancy Complications, Cardiovascular; Hypertension; Calcium; Pregnancy Outcome; Risk Factors; Parity; Pregnancy; Pregnancy Trimester, Second; Adult; Australia; Female; Obstetric Labor, Premature
RMID: 0030006426
DOI: 10.1111/j.1479-828X.1999.tb03434.x
Appears in Collections:Public Health publications

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