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https://hdl.handle.net/2440/4153
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Type: | Journal article |
Title: | Role of medical history in brain tumor development. Results fromthe international adult brain tumour study |
Author: | Schlehofer, B. Blettner, M. Preston-Martin, S. Niehoff, D. Wahrendorf, J. Arslan, A. Ahlbom, A. Choi, W. Giles, G. Howe, G. Little, J. Menegoz, F. Ryan, P. |
Citation: | International Journal of Cancer, 1999; 82(2):155-160 |
Publisher: | WILEY |
Issue Date: | 1999 |
ISSN: | 0020-7136 1097-0215 |
Statement of Responsibility: | Brigitte Schlehofer, Maria Blettner, Susan Preston-Martin, Dorothea Niehoff, Jürgen Wahrendorf, Annie Arslan, Anders Ahlbom, Won N. Choi, Graham G. Giles, Geoffrey R. Howe, Julian Little, Francois Ménégoz, Philip Ryan |
Abstract: | In an international population-based case-control study carried out in 8 centres in 6 countries, we investigated the role of specific medical conditions in the aetiology of brain tumours in adults. Recruited were 1,178 glioma and 331 meningioma cases and 2,493 age- and gender-matched population controls. Only medical conditions occurring at least 2 years before brain tumour diagnosis were considered. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using a conditional logistic regression model. Heterogeneity between centres was tested. No association between meningioma and previous medical conditions was observed. For glioma, there was an increased risk associated with epilepsy (RR = 6.55, 95% CI 3.40-12.63), but this was considerably weaker for epilepsy of more than 20 years duration. The risk remained elevated after adjustment for use of anti-epileptic drugs. There was a statistically significant inverse association between glioma and all allergic diseases combined (RR = 0.59, 95% CI 0.49-0.71); this was also observed for specific allergic conditions, namely, asthma and eczema. Subjects who reported a history of infectious diseases (e.g., colds, flu) showed a 30% reduction in risk (RR = 0.72, 95% CI 0.61-0.85). The decreased risks for glioma in subjects reporting a history of allergic conditions or infectious diseases may indicate an influence of immunological factors on the development of glioma. The association between glioma and epilepsy has to be interpreted cautiously and needs further investigation. |
Keywords: | Humans Glioma Meningioma Brain Neoplasms Nervous System Diseases Epilepsy Genetic Diseases, Inborn Hypersensitivity Contraceptives, Oral, Hormonal Anticonvulsants Anti-Allergic Agents Reproductive History Hormone Replacement Therapy Risk Risk Factors Case-Control Studies Retrospective Studies Mental Disorders Comorbidity Adult Aged Aged, 80 and over Middle Aged Drug Utilization Female Male Surveys and Questionnaires Infections |
DOI: | 10.1002/(SICI)1097-0215(19990719)82:2<155::AID-IJC1>3.0.CO;2-P |
Published version: | http://dx.doi.org/10.1002/(sici)1097-0215(19990719)82:2%3C155::aid-ijc1%3E3.0.co;2-p |
Appears in Collections: | Aurora harvest Public Health publications |
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