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https://hdl.handle.net/2440/44339
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Type: | Journal article |
Title: | Maternal birthweight and outcome of twin pregnancy |
Author: | Morley, R. Moore, V. Dwyer, T. Owens, J. Umstad, M. Carlin, J. |
Citation: | Paediatric and Perinatal Epidemiology, 2007; 21(6):501-506 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2007 |
ISSN: | 0269-5022 1365-3016 |
Statement of Responsibility: | Ruth Morley, Vivienne M. Moore, Terence Dwyer, Julie A. Owens, Mark P. Umstad and John B. Carlin |
Abstract: | There is evidence from singletons that maternal birthweight is positively related to offspring gestational length and birthweight, and some evidence of an inverse relationship with preterm birth. Among twins very preterm birth is the major cause of neonatal mortality and of immediate and later morbidity, including neurodevelopmental impairment. We hypothesised that the relationship between maternal birthweight and gestational length would be more evident in twin than in singleton pregnancies, as there is more variation in gestation in the former. Among 131 singleton mothers carrying twins, there was weak evidence of a positive relationship between maternal birthweight and twin gestational length (+0.6 weeks [95% CI −0.05, +1.3] per kg increase in maternal birthweight, but stronger evidence among 56 of these who went into labour spontaneously (+1.9 weeks [+0.7, +3.1], P = 0.003 for interaction). In the latter group we estimated that the odds of very preterm birth (at <32 weeks) were reduced by 50% [95% CI 10%, 82%] per 250 g increase in maternal birthweight. In the whole cohort, and in this subgroup, maternal birthweight was strongly positively related to both twin offspring total birthweight and total placental weight. Our data, consistent with intergenerational programming of early development, suggest the possibility of a stronger and more clinically relevant association among twins than among singletons. Nevertheless, our sample size was modest and this finding needs to be confirmed in a larger cohort. |
Keywords: | Placenta Humans Premature Birth Birth Weight Body Height Organ Size Pregnancy Outcome Odds Ratio Cohort Studies Gestational Age Pregnancy Pregnancy, Multiple Twins Infant, Newborn Female Male |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1111/j.1365-3016.2007.00848.x |
Published version: | http://dx.doi.org/10.1111/j.1365-3016.2007.00848.x |
Appears in Collections: | Aurora harvest 6 Public Health publications |
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