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Type: Journal article
Title: Bacterial degradation of microcystin toxins in drinking water eliminates their toxicity
Author: Ho, L.
Gaudieux, A.
Fanok, S.
Newcombe, G.
Humpage, A.
Citation: Toxicon, 2007; 50(3):438-441
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2007
ISSN: 0041-0101
Statement of
Lionel Ho, Anne-Laure Gaudieux, Stella Fanok, Gayle Newcombe and Andrew R. Humpage
Abstract: Microcystin-LR and -LA were readily biodegraded by a bacterium, Sphingpoyxis sp. LH21, in a treated reservoir water. Detection of the microcystins was conducted using high-performance liquid chromatography (HPLC), protein phosphatase 2A (PP2A) inhibition assay and a cell-based cytotoxicity assay. The HPLC results correlated well with the two assays. The decrease in cytotoxicity, coupled with the associated decrease in microcystin concentrations, indicated that no cytotoxic by-products were being generated, highlighting the applicability of biodegradation as a feasible treatment option for effective microcystin removal.
Keywords: Vero Cells; Animals; Cercopithecus aethiops; Alphaproteobacteria; Water; Biodegradation, Environmental; Microcystins
Description: Copyright © 2007 Elsevier Ltd All rights reserved.
RMID: 0020077090
DOI: 10.1016/j.toxicon.2007.03.021
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Appears in Collections:Pharmacology publications
Environment Institute publications

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