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|Title:||Bacterial degradation of microcystin toxins in drinking water eliminates their toxicity|
|Citation:||Toxicon, 2007; 50(3):438-441|
|Publisher:||Pergamon-Elsevier Science Ltd|
|Lionel Ho, Anne-Laure Gaudieux, Stella Fanok, Gayle Newcombe and Andrew R. Humpage|
|Abstract:||Microcystin-LR and -LA were readily biodegraded by a bacterium, Sphingpoyxis sp. LH21, in a treated reservoir water. Detection of the microcystins was conducted using high-performance liquid chromatography (HPLC), protein phosphatase 2A (PP2A) inhibition assay and a cell-based cytotoxicity assay. The HPLC results correlated well with the two assays. The decrease in cytotoxicity, coupled with the associated decrease in microcystin concentrations, indicated that no cytotoxic by-products were being generated, highlighting the applicability of biodegradation as a feasible treatment option for effective microcystin removal.|
|Keywords:||Vero Cells; Animals; Cercopithecus aethiops; Alphaproteobacteria; Water; Biodegradation, Environmental; Microcystins|
|Description:||Copyright © 2007 Elsevier Ltd All rights reserved.|
|Appears in Collections:||Pharmacology publications|
Environment Institute publications
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