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https://hdl.handle.net/2440/47174
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Type: | Journal article |
Title: | A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses |
Author: | Brooks, S. Lear, T. Adelson, D. Bailey, E. |
Citation: | Cytogenetic and Genome Research, 2007; 119(3-4):225-230 |
Publisher: | Karger |
Issue Date: | 2007 |
ISSN: | 1424-8581 1424-859X |
Statement of Responsibility: | S.A. Brooks, T.L. Lear, D.L. Adelson, E. Bailey |
Abstract: | Tobiano is a white spotting pattern in horses caused by a dominant gene, Tobiano(TO). Here, we report TO associated with a large paracentric chromosome inversion on horse chromosome 3. DNA sequences flanking the inversion were identified and a PCR test was developed to detect the inversion. The inversion was only found in horses with the tobiano pattern, including horses with diverse genetic backgrounds, which indicated a common genetic origin thousands of years ago. The inversion does not interrupt any annotated genes, but begins approximately 100 kb downstream of the KIT gene. This inversion may disrupt regulatory sequences for the KIT gene and cause the white spotting pattern. |
Keywords: | Chromosomes, Mammalian Animals Horses Albumins Vitamin D-Binding Protein Genetic Markers Pigmentation In Situ Hybridization, Fluorescence Polymerase Chain Reaction Breeding Haplotypes Polymorphism, Single Nucleotide Molecular Sequence Data Proto-Oncogene Proteins c-kit Chromosome Inversion |
Rights: | Copyright © 2007 S. Karger AG, Basel |
DOI: | 10.1159/000112065 |
Published version: | http://dx.doi.org/10.1159/000112065 |
Appears in Collections: | Aurora harvest Environment Institute publications Molecular and Biomedical Science publications |
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