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Type: Journal article
Title: The effect of functional gastrointestinal disorders on psychological comorbidity and quality of life in patients with inflammatory bowel disease
Author: Mikocka-Walus, A.
Turnbull, D.
Andrews, J.
Moulding, N.
Holtmann, G.
Citation: Alimentary Pharmacology & Therapeutics, 2008; 28(4):475-483
Publisher: Blackwell Publishing Ltd
Issue Date: 2008
ISSN: 0269-2813
Statement of
A. A. Mikocka-Walus, D. A. Turnbull, J. M. Andrews, N. T. Moulding & G. J. Holtmann
Abstract: BACKGROUND: Symptoms of functional gastrointestinal disorders (FGIDs) are common in patients with inflammatory bowel disease (IBD). Psychological comorbidities of anxiety and depression are also highly prevalent in IBD. AIM: To quantify the burden of FGIDs in a hospital-based cohort of patients with IBD and to determine whether there is any inter-relationship between the presence and number of FGIDs and patients' quality of life or psychological status. METHODS: A cross-sectional survey of 61 out-patients was performed. Data on psychological status, quality of life, disease activity and functional symptoms according to Rome III criteria were collected. RESULTS: Overall, 49 (80%) participants met Rome III criteria for a functional bowel disorder and 52% of participants met criteria for more than one FGID. Participants with no FGID had significantly better physical quality of life than those with more than two FGIDs (P = 0.025). However, there was no relationship among the number of FGIDs, mental quality of life, anxiety or depression. CONCLUSIONS: Functional gastrointestinal disorders are highly prevalent in out-patients with IBD. Somewhat unexpectedly, the presence of anxiety and/or depression did not appear to correlate with either the presence or the number of FGIDs.
Keywords: Humans; Inflammatory Bowel Diseases; Questionnaires; Anxiety Disorders; Depressive Disorder; Quality of Life; Adult; Aged; Aged, 80 and over; Middle Aged; Female; Male
Description: The definitive version may be found at
RMID: 0020082349
DOI: 10.1111/j.1365-2036.2008.03754.x
Appears in Collections:Psychology publications

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