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https://hdl.handle.net/2440/58230
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Type: | Journal article |
Title: | Dose-dependent increases in heart rate variability and arterial compliance in overweight and obese adults with DHA-rich fish oil supplementation |
Author: | Sjoberg, N. Milte, C. Buckley, J. Howe, P. Coates, A. Saint, D. |
Citation: | The British Journal of Nutrition: an international journal of nutritional science, 2010; 103(2):243-248 |
Publisher: | C A B I Publishing |
Issue Date: | 2010 |
ISSN: | 0007-1145 1475-2662 |
Statement of Responsibility: | Nicholas J. Sjoberg, Catherine M. Milte, Jonathan D. Buckley, Peter R. C. Howe, Alison M. Coates and David A. Saint |
Abstract: | Heart rate (HR) variability and large arterial compliance can be improved using fish oils. DHA, a component of fish oil, has cardiovascular health benefits, but its effect on HR variability (HRV) and arterial compliance is yet to be quantified. Sixty-seven overweight or obese adults (thirty-six males and thirty-one females; 53 (SEM 2) year; BMI 31•7 (SEM 1•1) kg/m2) were randomly allocated to consume either 6 g/d sunola oil (control; n 17), fish oil (260 mg DHA þ 60 mg EPA per g) at doses of 2 g/d (n 16), 4 g/d (n 17) or 6 g/d (n 17). Blood pressure, HR and compliance of large and small arteries were measured while supine at baseline and after 12 weeks in all participants, and HRV was assessed in a subgroup of forty-six participants. There was no effect of fish oil on blood pressure, small artery compliance or HR. However, the low frequency:high frequency ratio of HRV decreased with increasing doses of fish oil (r 20•34, P¼0•02), while large artery compliance increased (r 0•34, P¼0•006). Moreover, the changes in these biomarkers were significantly correlated (r 20•31, P¼0•04) and may reflect fish oil-induced improvements in arterial function and cardiac autonomic regulation. |
Keywords: | n-3 PUFA DHA Cardiovascular health Cardiac autonomic balance |
Rights: | Copyright The Authors 2009 |
DOI: | 10.1017/S000711450999153X |
Grant ID: | http://purl.org/au-research/grants/arc/LP0561211 http://purl.org/au-research/grants/arc/LP0561211 |
Published version: | http://dx.doi.org/10.1017/s000711450999153x |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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