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https://hdl.handle.net/2440/58657
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Type: | Journal article |
Title: | Proton-pump inhibitors and the risk of antibiotic use and hospitalisation for pneumonia |
Author: | Roughead, E. Ramsay, E. Pratt, N. Ryan, P. Gilbert, A. |
Citation: | Medical Journal of Australia, 2009; 190(3):114-116 |
Publisher: | Australasian Med Publ Co Ltd |
Issue Date: | 2009 |
ISSN: | 0025-729X 1326-5377 |
Statement of Responsibility: | Elizabeth E Roughead, Emmae N Ramsay, Nicole L Pratt, Philip Ryan and Andrew L Gilbert |
Abstract: | Objective: To determine whether proton-pump inhibitor (PPI) use is associated with hospitalisations for pneumonia and with antibiotic use. Design and setting: Historical cohort study in the Australian veteran population, conducted from 1 January 2002 to 30 December 2006, comparing veterans exposed to PPIs with those not exposed. Participants: All 185 533 veterans who were Gold Card holders (ie, eligible for all health services subsidised by the Department of Veterans’ Affairs) and aged 65 years and over at 1 January 2002 and had been prescribed at least one medicine in the previous 6 months. Main outcome measures: The primary endpoint was hospitalisation for pneumonia. Secondary endpoints included hospitalisation for bacterial pneumonia and dispensings of antibiotics commonly used to treat respiratory tract infections. Results: After adjustment for potential confounders, we found an increased risk of hospitalisation for pneumonia among those exposed to PPIs compared with the unexposed group (rate ratio [RR], 1.16; 95% CI, 1.11–1.22). The risk was not increased for bacterial pneumonia (RR, 1.13; 95% CI, 0.98–1.31), which made up 8% of pneumonia cases. An increased risk of antibiotic dispensings was observed among those exposed to PPIs (RR, 1.23; 95% CI, 1.21–1.24). Conclusions: PPI dispensings were found to be associated with a small but significant increased risk of hospitalisation for pneumonia. While the increased risk is small, the prevalent use of PPIs means that many people could be affected. |
Keywords: | Humans Pneumonia, Bacterial Anti-Bacterial Agents Hospitalization Confidence Intervals Risk Assessment Risk Factors Cohort Studies Aged Veterans Disability Claims Drug Utilization Australia Female Male Proton Pump Inhibitors |
Rights: | © The Medical Journal of Australia 2009 |
DOI: | 10.5694/j.1326-5377.2009.tb02307.x |
Published version: | http://www.mja.com.au/public/issues/190_03_020209/rou10521_fm.html |
Appears in Collections: | Aurora harvest Public Health publications |
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