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https://hdl.handle.net/2440/60320
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Type: | Journal article |
Title: | Long-term effects of weight loss with a very low carbohydrate and low fat diet on vascular function in overweight and obese patients |
Author: | Wycherley, T. Brinkworth, G. Keogh, J. Noakes, M. Buckley, J. Clifton, P. |
Citation: | Journal of Internal Medicine, 2010; 267(5):452-461 |
Publisher: | Blackwell Science Ltd |
Issue Date: | 2010 |
ISSN: | 0954-6820 1365-2796 |
Statement of Responsibility: | T. P. Wycherley, G. D. Brinkworth, J.B. Keogh, M.Noakes, J. D.Buckley and P. M.Clifton |
Abstract: | <h4>Objective</h4>To compare the effects of an energy reduced very low carbohydrate, high saturated fat diet (LC) and an isocaloric high carbohydrate, low fat diet (LF) on endothelial function after 12 months.<h4>Design and subjects</h4>Forty-nine overweight or obese patients (age 50.0 +/- 1.1 years, BMI 33.7 +/- 0.6 kg m(-2)) were randomized to either an energy restricted ( approximately 6-7 MJ), planned isocaloric LC or LF for 52 weeks. Body weight, endothelium-derived factors, flow-mediated dilatation (FMD), adiponectin, augmentation index (AIx) and pulse wave velocity (PWV) were assessed. All data are mean +/- SEM.<h4>Results</h4>Weight loss was similar in both groups (LC -14.9 +/- 2.1 kg, LF -11.5 +/- 1.5 kg; P = 0.20). There was a significant time x diet effect for FMD (P = 0.045); FMD decreased in LC (5.7 +/- 0.7% to 3.7 +/- 0.5%) but remained unchanged in LF (5.9 +/- 0.5% to 5.5 +/- 0.7%). PWV improved in both groups (LC -1.4 +/- 0.6 m s(-1), LF -1.5 +/- 0.6 m s(-1); P = 0.001 for time) with no diet effect (P = 0.80). AIx and VCAM-1 did not change in either group. Adiponectin, eSelectin, tPA and PAI-1 improved similarly in both groups (P < 0.01 for time).<h4>Conclusion</h4>Both LC and LF hypoenergetic diets achieved similar reductions in body weight and were associated with improvements in PWV and a number of endothelium-derived factors. However, the LC diet impaired FMD suggesting chronic consumption of a LC diet may have detrimental effects on endothelial function. |
Keywords: | cardiovascular disease endothelial function flow-mediateddilatation |
Rights: | Copyright 2010 Blackwell Publishing |
DOI: | 10.1111/j.1365-2796.2009.02174.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2796.2009.02174.x |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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