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https://hdl.handle.net/2440/61253
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Type: | Journal article |
Title: | DNA binding and aggregation by carbon nanoparticles |
Author: | An, H. Liu, Q. Ji, Q. Jin, B. |
Citation: | Biochemical and Biophysical Research Communications, 2010; 393(4):571-576 |
Publisher: | Academic Press Inc |
Issue Date: | 2010 |
ISSN: | 0006-291X 1090-2104 |
Statement of Responsibility: | Hongjie An, Qingdai Liu, Qiaoli Ji, Bo Jin |
Abstract: | Significant environmental and health risks due to the increasing applications of engineered nanoparticles in medical and industrial activities have been concerned by many communities. The interactions between nanomaterials and genomes have been poorly studied so far. This study examined interactions of DNA with carbon nanoparticles (CNP) using atomic force microscopy (AFM). We experimentally assessed how CNP affect DNA molecule and bacterial growth of Escherichia coli. We found that CNP were bound to the DNA molecules during the DNA replication in vivo. The results revealed that the interaction of DNA with CNP resulted in DNA molecule binding and aggregation both in vivo and in vitro in a dose-dependent manner, and consequently inhabiting the E. coli growth. While this was a preliminary study, our results showed that this nanoparticle may have a significant impact on genomic activities. |
Keywords: | Carbon nanoparticles (CNP) DNA Binding Aggregation Atomic force microscopy (AFM) |
Rights: | Copyright © 2010 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.bbrc.2010.02.006 |
Published version: | http://dx.doi.org/10.1016/j.bbrc.2010.02.006 |
Appears in Collections: | Aurora harvest Earth and Environmental Sciences publications Environment Institute publications |
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