Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/61345
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Type: Journal article
Title: Primary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up study
Author: Saeed, P.
Blank, L.
Selva-Nayagam, D.
Wolbers, J.
Nowak, P.
Geskus, R.
Weis, E.
Mourits, M.
Rootman, J.
Citation: British Journal of Ophthalmology, 2010; 94(5):564-568
Publisher: British Med Journal Publ Group
Issue Date: 2010
ISSN: 0007-1161
1468-2079
Statement of
Responsibility: 
Peerooz Saeed, Leo Blank, Dinesh Selva, John G. Wolbers, Peter J.C.M. Nowak, Ronald B. Geskus, Ezekiel Weis, Maarten P. Mourits, Jack Rootman
Abstract: Background/aims: To report the outcome of primary radiotherapy in patients with progressive optic nerve sheath meningioma (ONSM). Methods: The clinical records of all patients were reviewed in a retrospective, observational, multicentre study. Results: Thirty-four consecutive patients were included. Twenty-six women and eight men received conventional or stereotactic fractionated radiotherapy, and were followed for a median 58 (range 51–156) months. Fourteen eyes (41%) showed improved visual acuity of at least two lines on the Snellen chart. In 17 (50%) eyes, the vision stabilised, while deterioration was noted in three eyes (9%). The visual outcome was not associated with age at the time of radiotherapy (p=0.83), sex (p=0.43), visual acuity at the time of presentation (p=0.22) or type of radiotherapy (p=0.35). Optic disc swelling was associated with improved visual acuity (p<0.01) and 4/11 patients with optic atrophy also showed improvement. Long-term complications were dry eyes in five patients, cataracts in three, and mild radiation retinopathy in four. Conclusion: Primary radiotherapy for patients with ONSM is associated with long-term improvement of visual acuity and few adverse effects.
Keywords: Humans; Meningioma; Optic Nerve Neoplasms; Vision Disorders; Dry Eye Syndromes; Retinal Diseases; Radiation Injuries; Disease Progression; Prognosis; Treatment Outcome; Retrospective Studies; Follow-Up Studies; Sex Distribution; Visual Acuity; Visual Fields; Adolescent; Adult; Aged; Middle Aged; Child; Female; Male
Rights: Copyright © The Authors
RMID: 0020097384
DOI: 10.1136/bjo.2009.166793
Appears in Collections:Opthalmology & Visual Sciences publications

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