Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/61345
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Type: | Journal article |
Title: | Primary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up study |
Author: | Saeed, P. Blank, L. Selva-Nayagam, D. Wolbers, J. Nowak, P. Geskus, R. Weis, E. Mourits, M. Rootman, J. |
Citation: | British Journal of Ophthalmology, 2010; 94(5):564-568 |
Publisher: | British Med Journal Publ Group |
Issue Date: | 2010 |
ISSN: | 0007-1161 1468-2079 |
Statement of Responsibility: | Peerooz Saeed, Leo Blank, Dinesh Selva, John G. Wolbers, Peter J.C.M. Nowak, Ronald B. Geskus, Ezekiel Weis, Maarten P. Mourits, Jack Rootman |
Abstract: | Background/aims: To report the outcome of primary radiotherapy in patients with progressive optic nerve sheath meningioma (ONSM). Methods: The clinical records of all patients were reviewed in a retrospective, observational, multicentre study. Results: Thirty-four consecutive patients were included. Twenty-six women and eight men received conventional or stereotactic fractionated radiotherapy, and were followed for a median 58 (range 51–156) months. Fourteen eyes (41%) showed improved visual acuity of at least two lines on the Snellen chart. In 17 (50%) eyes, the vision stabilised, while deterioration was noted in three eyes (9%). The visual outcome was not associated with age at the time of radiotherapy (p=0.83), sex (p=0.43), visual acuity at the time of presentation (p=0.22) or type of radiotherapy (p=0.35). Optic disc swelling was associated with improved visual acuity (p<0.01) and 4/11 patients with optic atrophy also showed improvement. Long-term complications were dry eyes in five patients, cataracts in three, and mild radiation retinopathy in four. Conclusion: Primary radiotherapy for patients with ONSM is associated with long-term improvement of visual acuity and few adverse effects. |
Keywords: | Humans Meningioma Optic Nerve Neoplasms Vision Disorders Dry Eye Syndromes Retinal Diseases Radiation Injuries Disease Progression Prognosis Treatment Outcome Retrospective Studies Follow-Up Studies Sex Distribution Visual Acuity Visual Fields Adolescent Adult Aged Middle Aged Child Female Male |
Rights: | Copyright © The Authors |
DOI: | 10.1136/bjo.2009.166793 |
Published version: | http://dx.doi.org/10.1136/bjo.2009.166793 |
Appears in Collections: | Aurora harvest Opthalmology & Visual Sciences publications |
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hdl_61345.pdf | Published version | 94.96 kB | Adobe PDF | View/Open |
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