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https://hdl.handle.net/2440/65617
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Type: | Journal article |
Title: | The transition from fetal growth restriction to accelerated postnatal growth: a potential role for insulin signalling in skeletal muscle |
Author: | Muhlhausler, B. Duffield, J. Ozanne, S. Pilgrim, C. Turner, N. Morrison, J. McMillen, I. |
Citation: | The Journal of Physiology, 2009; 587(17):4199-4211 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2009 |
ISSN: | 0022-3751 1469-7793 |
Statement of Responsibility: | B. S. Muhlhausler, J. A. Duffield, S. E. Ozanne, C. Pilgrim, N. Turner, J. L. Morrison and I. C. McMillen |
Abstract: | A world-wide series of epidemiological and experimental studies have demonstrated that there is an association between being small at birth, accelerated growth in early postnatal life and the emergence of insulin resistance in adult life. The aim of this study was to investigate why accelerated growth occurs in postnatal life after in utero growth restriction. Samples of quadriceps muscle were collected at ∼140 days gestation (term ∼150 days gestation) from normally grown fetal lambs (Control, n = 7) and from growth restricted fetal lambs (placentally restricted: PR, n = 8) and from Control (n = 14) and PR (n = 9) lambs at 21 days after birth. The abundance of the insulin and IGF1 receptor protein was higher in the quadriceps muscle of the PR fetus, but there was a lower abundance of the insulin signalling molecule PKCζ, and GLUT4 protein in the PR group. At 21 days of postnatal age, insulin receptor abundance remained higher in the muscle of the PR lamb, and there was also an up-regulation of the insulin signalling molecules, PI3Kinase p85, Akt1 and Akt2 and of the GLUT4 protein in the PR group. Fetal growth restriction therefore results in an increased abundance of the insulin receptor in skeletal muscle, which persists after birth when it is associated with an upregulation of insulin signalling molecules and the glucose transporter, GLUT4. These data provide evidence that the origins of the accelerated growth experienced by the small baby after birth lie in the adaptive response of the growth restricted fetus to its low placental substrate supply. |
Keywords: | Muscle, Skeletal Animals Sheep Fetal Growth Retardation Insulin Signal Transduction Fetal Development Pregnancy Models, Biological Female |
Rights: | © 2009 The Authors. Journal compilation © 2009 The Physiological Society |
DOI: | 10.1113/jphysiol.2009.173161 |
Published version: | http://dx.doi.org/10.1113/jphysiol.2009.173161 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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