Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/66871
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Type: Journal article
Title: Effects of Merogel coverage on wound healing and ostial patency in endonasal endoscopic dacryocystorhinostomy for primary chronic dacryocystitis
Author: Wu, W.
Cannon, P.
Yan, W.
Tu, Y.
Selva-Nayagam, D.
Qu, J.
Citation: Eye, 2011; 25(6):746-753
Publisher: Nature Publishing Group
Issue Date: 2011
ISSN: 0950-222X
1476-5454
Statement of
Responsibility: 
W Wu, PS Cannon, W Yan, Y Tu, D Selva and J Qu
Abstract: Purpose: To investigate the effects of Merogel coverage on ostial patency in endonasal endoscopic dacryocystorhinostomy (EES-DCR) for primary chronic dacryocystitis (PCD). Methods: In all, 260 patients with unilateral PCD were randomized into two groups: the Merogel group and the control group. All patients underwent EES-DCR. The Merogel group received Merogel covering the wound 1–2 mm around the ostium and the control group received no treatment. Patients were followed up for 9 months. The mucosal epithelialization of the wound, the proliferation of fibrosis tissue, and the success rate of ostial patency were compared. Results: Our study included 112 patients in the Merogel group and 115 patients in the control group. At the 2-week review, intact mucosal epithelium lined the ostia in 96 Merogel patients compared with 80 control patients (ITT analysis: χ ²=4.502, P=0.034). At the 9-month review, scars were present in 18 patients in the Merogel group compared with 39 patients in the control group (ITT analysis: χ ²=9.909, P=0.002, ITT analysis). No differences were observed in the granulation formation between the two groups. The success rate of ostial patency reached 94.6% (106/112) in the Merogel group compared with 80% (92/115) in the control group (ITT analysis: χ ²=4.151, P=0.042). Conclusion: Merogel coverage may enhance the success rate of EES-DCR for PCD by promoting mucosal epithelial healing and preventing excessive scarring.
Keywords: endonasal endoscopic dacryocystorhinostomy; hyaluronan; ostial patency; mucosa epithelialization; primary chronic dacryocystitis
Rights: © 2011 Macmillan Publishers Limited. All rights reserved.
RMID: 0020109917
DOI: 10.1038/eye.2011.44
Appears in Collections:Opthalmology & Visual Sciences publications

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