Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/68183
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Type: Journal article
Title: Protection of retinal ganglion cells and the optic nerve during short-term hyperglycemia in experimental glaucoma
Author: Ebneter, A.
Chidlow, G.
Wood, J.
Casson, R.
Citation: JAMA Ophthalmology, 2011; 129(10):1337-1344
Publisher: Amer Medical Assoc
Issue Date: 2011
ISSN: 0003-9950
1538-3601
Statement of
Responsibility: 
Andreas Ebneter, Glyn Chidlow, John P. M. Wood, Robert J. Casson
Abstract: Objective: To evaluate the neuroprotective effect of short-term hyperglycemia on the retinal ganglion cell body and axon in a rat model of experimental glaucoma. Methods: Using a well-described limbal laser technique, unilateral ocular hypertension was induced in 2 groups (26 per group) of Sprague-Dawley rats. One group remained normoglycemic; the other was rendered hyperglycemic by means of an intraperitoneal injection of streptozocin. After 2 weeks of elevated intraocular pressure, axonal and retinal damage profiles were compared using several histological techniques. Immunohistochemical changes in the retina and optic nerve were also assessed. Results: We found convincing evidence of delayed axonal degeneration and retinal ganglion cell death in hyperglycemic rats. Axon loss was reduced by about 50% 2 weeks after induction of ocular hypertension. Survival of retinal ganglion cell perikarya increased to a similar extent in hyperglycemic rats. Conclusions: The optic nerve and retinal ganglion cells are partially protected by short-term hyperglycemia in this rat model of experimental glaucoma. Energy substrate availability may therefore play a role in glaucomatous optic neuropathy.
Keywords: Axons
Retinal Ganglion Cells
Animals
Rats
Rats, Sprague-Dawley
Optic Nerve Diseases
Ocular Hypertension
Diabetes Mellitus, Experimental
Hyperglycemia
Nerve Degeneration
Blood Glucose
Nerve Tissue Proteins
Tonometry, Ocular
Cell Count
Immunohistochemistry
Cell Survival
Intraocular Pressure
Cytoprotection
Biomarkers
Rights: ©2011 American Medical Association. All rights reserved.
DOI: 10.1001/archophthalmol.2011.269
Grant ID: http://purl.org/au-research/grants/nhmrc/626964
Published version: http://dx.doi.org/10.1001/archophthalmol.2011.269
Appears in Collections:Aurora harvest 5
Opthalmology & Visual Sciences publications

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