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https://hdl.handle.net/2440/68183
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Type: | Journal article |
Title: | Protection of retinal ganglion cells and the optic nerve during short-term hyperglycemia in experimental glaucoma |
Author: | Ebneter, A. Chidlow, G. Wood, J. Casson, R. |
Citation: | JAMA Ophthalmology, 2011; 129(10):1337-1344 |
Publisher: | Amer Medical Assoc |
Issue Date: | 2011 |
ISSN: | 0003-9950 1538-3601 |
Statement of Responsibility: | Andreas Ebneter, Glyn Chidlow, John P. M. Wood, Robert J. Casson |
Abstract: | Objective: To evaluate the neuroprotective effect of short-term hyperglycemia on the retinal ganglion cell body and axon in a rat model of experimental glaucoma. Methods: Using a well-described limbal laser technique, unilateral ocular hypertension was induced in 2 groups (26 per group) of Sprague-Dawley rats. One group remained normoglycemic; the other was rendered hyperglycemic by means of an intraperitoneal injection of streptozocin. After 2 weeks of elevated intraocular pressure, axonal and retinal damage profiles were compared using several histological techniques. Immunohistochemical changes in the retina and optic nerve were also assessed. Results: We found convincing evidence of delayed axonal degeneration and retinal ganglion cell death in hyperglycemic rats. Axon loss was reduced by about 50% 2 weeks after induction of ocular hypertension. Survival of retinal ganglion cell perikarya increased to a similar extent in hyperglycemic rats. Conclusions: The optic nerve and retinal ganglion cells are partially protected by short-term hyperglycemia in this rat model of experimental glaucoma. Energy substrate availability may therefore play a role in glaucomatous optic neuropathy. |
Keywords: | Axons Retinal Ganglion Cells Animals Rats Rats, Sprague-Dawley Optic Nerve Diseases Ocular Hypertension Diabetes Mellitus, Experimental Hyperglycemia Nerve Degeneration Blood Glucose Nerve Tissue Proteins Tonometry, Ocular Cell Count Immunohistochemistry Cell Survival Intraocular Pressure Cytoprotection Biomarkers |
Rights: | ©2011 American Medical Association. All rights reserved. |
DOI: | 10.1001/archophthalmol.2011.269 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/626964 |
Published version: | http://dx.doi.org/10.1001/archophthalmol.2011.269 |
Appears in Collections: | Aurora harvest 5 Opthalmology & Visual Sciences publications |
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