Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/69003
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Type: Journal article
Title: Deteriorating pneumococcal-specific B-cell memory in minimally symptomatic African children with HIV infection
Author: Iwajomo, O.
Finn, A.
Moons, P.
Nkhata, R.
Sepako, E.
Ogunniyi, A.
Williams, N.
Heyderman, R.
Citation: The Journal of Infectious Diseases, 2011; 204(4):534-543
Publisher: Oxford University Press
Issue Date: 2011
ISSN: 1537-6613
1537-6613
Statement of
Responsibility: 
Oluwadamilola H. Iwajomo, Adam Finn, Peter Moons, Rose Nkhata, Enoch Sepako, Abiodun D. Ogunniyi, Neil A. Williams, and Robert S. Heyderman
Abstract: Invasive pneumococcal disease is a leading cause of human immunodeficiency virus (HIV)–associated mortality in sub-Saharan African children. Defective T-cell–mediated immunity partially explains this high disease burden, but there is an increased risk of invasive pneumococcal disease even in the context of a relatively preserved percentage of CD4 cells. We hypothesized that impaired B-cell immunity to this pathogen further amplifies the immune defect. We report a shift in the B-cell compartment toward an apoptosis-prone phenotype evident early in HIV disease progression. We show that, although healthy HIV-uninfected and minimally symptomatic HIV-infected children have similar numbers of isotype-switched memory B cells, numbers of pneumococcal protein antigen–specific memory B cells were lower in HIV-infected than in HIV-uninfected children. Our data implicate defective naturally acquired B-cell pneumococcal immunity in invasive pneumococcal disease causation in HIV-infected children and highlight the need to study the functionality and duration of immune memory to novel pneumococcal protein vaccine candidates in order to optimize their effectiveness in this population.
Keywords: B-Lymphocytes; CD4-Positive T-Lymphocytes; Humans; Streptococcus pneumoniae; Pneumococcal Infections; HIV Infections; Immunoglobulin G; Immunoglobulin M; CD40 Ligand; CD4 Lymphocyte Count; Carrier State; Immunoglobulin Class Switching; Immunologic Memory; Child; Child, Preschool; Infant; Malawi; Female; Male; Enzyme-Linked Immunospot Assay
Rights: © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
RMID: 0020111537
DOI: 10.1093/infdis/jir316
Appears in Collections:Molecular and Biomedical Science publications

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