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Type: Journal article
Title: Hepatocellular carcinoma following neonatal hepatitis
Author: Moore, L.
Bourne, A.
Moore, D.
Preston, H.
Byard, R.
Citation: Pediatric Pathology and Laboratory Medicine, 1997; 17(4):601-610
Issue Date: 1997
ISSN: 1077-1042
Statement of
Lynette Moore; Anthony J. Bourne; BS David J. Moore; BS Henry Preston; BS Roger W. Byard
Abstract: Hepatocellular carcinoma is an uncommon malignancy in young children associated with a variety of congenital and acquired conditions. It has been generally held that idiopathic neonatal hepatitis is not an antecedent of hepatocellular neoplasia in childhood. We report a 28-month-old girl in whom a diagnosis of neonatal giant cell hepatitis was confirmed by liver biopsy at 4 months of age who was followed up with serial liver biopsies. Hepatitis B and C virus infection and metabolic abnormalities had been excluded by appropriate testing. There was no history of parenteral nutrition. The morphologic criteria for a diagnosis of cirrhosis were satisfied in a liver biopsy undertaken at 23 months of age. At 28 months a laparotomy was performed because of continuing jaundice and the development of an abdominal mass. Biopsy of the mass revealed a hepatocellular carcinoma. Ploidy studies showed an aneuploid tumor and a hyperdiploid karyotype was confirmed by chromosomal analysis. This case demonstrates by sequential biopsy the progression from neonatal hepatitis to cirrhosis and hepatocellular carcinoma in a young child.
Keywords: Giant Cells; Humans; Carcinoma, Hepatocellular; Liver Neoplasms; Hepatitis; Liver Cirrhosis; Jaundice, Neonatal; Biopsy, Needle; Flow Cytometry; Fatal Outcome; Child, Preschool; Infant, Newborn; Female
RMID: 0030005410
DOI: 10.1080/713601311
Appears in Collections:Paediatrics publications

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