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|Title:||Hepatocellular carcinoma following neonatal hepatitis|
|Citation:||Pediatric Pathology and Laboratory Medicine, 1997; 17(4):601-610|
|Publisher:||TAYLOR & FRANCIS|
|Lynette Moore; Anthony J. Bourne; BS David J. Moore; BS Henry Preston; BS Roger W. Byard|
|Abstract:||Hepatocellular carcinoma is an uncommon malignancy in young children associated with a variety of congenital and acquired conditions. It has been generally held that idiopathic neonatal hepatitis is not an antecedent of hepatocellular neoplasia in childhood. We report a 28-month-old girl in whom a diagnosis of neonatal giant cell hepatitis was confirmed by liver biopsy at 4 months of age who was followed up with serial liver biopsies. Hepatitis B and C virus infection and metabolic abnormalities had been excluded by appropriate testing. There was no history of parenteral nutrition. The morphologic criteria for a diagnosis of cirrhosis were satisfied in a liver biopsy undertaken at 23 months of age. At 28 months a laparotomy was performed because of continuing jaundice and the development of an abdominal mass. Biopsy of the mass revealed a hepatocellular carcinoma. Ploidy studies showed an aneuploid tumor and a hyperdiploid karyotype was confirmed by chromosomal analysis. This case demonstrates by sequential biopsy the progression from neonatal hepatitis to cirrhosis and hepatocellular carcinoma in a young child.|
|Keywords:||Giant Cells; Humans; Carcinoma, Hepatocellular; Liver Neoplasms; Hepatitis; Liver Cirrhosis; Jaundice, Neonatal; Biopsy, Needle; Flow Cytometry; Fatal Outcome; Child, Preschool; Infant, Newborn; Female|
|Appears in Collections:||Paediatrics publications|
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