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https://hdl.handle.net/2440/7782
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Type: | Journal article |
Title: | Hepatocellular carcinoma following neonatal hepatitis |
Author: | Moore, L. Bourne, A. Moore, D. Preston, H. Byard, R. |
Citation: | Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association, 1997; 17(4):601-610 |
Publisher: | TAYLOR & FRANCIS |
Issue Date: | 1997 |
ISSN: | 1077-1042 1087-6529 |
Statement of Responsibility: | Lynette Moore; Anthony J. Bourne; BS David J. Moore; BS Henry Preston; BS Roger W. Byard |
Abstract: | Hepatocellular carcinoma is an uncommon malignancy in young children associated with a variety of congenital and acquired conditions. It has been generally held that idiopathic neonatal hepatitis is not an antecedent of hepatocellular neoplasia in childhood. We report a 28-month-old girl in whom a diagnosis of neonatal giant cell hepatitis was confirmed by liver biopsy at 4 months of age who was followed up with serial liver biopsies. Hepatitis B and C virus infection and metabolic abnormalities had been excluded by appropriate testing. There was no history of parenteral nutrition. The morphologic criteria for a diagnosis of cirrhosis were satisfied in a liver biopsy undertaken at 23 months of age. At 28 months a laparotomy was performed because of continuing jaundice and the development of an abdominal mass. Biopsy of the mass revealed a hepatocellular carcinoma. Ploidy studies showed an aneuploid tumor and a hyperdiploid karyotype was confirmed by chromosomal analysis. This case demonstrates by sequential biopsy the progression from neonatal hepatitis to cirrhosis and hepatocellular carcinoma in a young child. |
Keywords: | Giant Cells Humans Carcinoma, Hepatocellular Liver Neoplasms Hepatitis Liver Cirrhosis Jaundice, Neonatal Biopsy, Needle Flow Cytometry Fatal Outcome Child, Preschool Infant, Newborn Female |
DOI: | 10.1080/713601311 |
Published version: | http://dx.doi.org/10.1080/107710497174570 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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