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https://hdl.handle.net/2440/79022
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Type: | Journal article |
Title: | Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata |
Author: | Boattini, A. Adler, C. Cooper, A. Dersarkissian, C. Haak, W. |
Citation: | PLoS One, 2013; 8(5):1-12 |
Publisher: | Public Library of Science |
Issue Date: | 2013 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Caramelli, D. |
Contributor: | Adler, Christina Jane Cooper, Alan Dersarkissian, Clio Simone Irmgard Haak, Wolfgang |
Statement of Responsibility: | Alessio Boattini, Begoña Martinez-Cruz, Stefania Sarno, Christine Harmant, Antonella Useli, Paula Sanz, Daniele Yang-Yao, Jeremy Manry, Graziella Ciani, Donata Luiselli, Lluis Quintana- Murci, David Comas, Davide Pettener, the Genographic Consortium |
Abstract: | Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Metal Ages and the most recent history of the two last millennia (involving the overlapping of different cultural and demic strata) has shaped the pattern of the modern Italian genetic structure. With the aim of disentangling this pattern and understanding which processes more importantly shaped the distribution of diversity, we have analyzed the uniparentally-inherited markers in ~900 individuals from an extensive sampling across the Italian peninsula, Sardinia and Sicily. Spatial PCAs and DAPCs revealed a sex-biased pattern indicating different demographic histories for males and females. Besides the genetic outlier position of Sardinians, a North West–South East Y-chromosome structure is found in continental Italy. Such structure is in agreement with recent archeological syntheses indicating two independent and parallel processes of Neolithisation. In addition, date estimates pinpoint the importance of the cultural and demographic events during the late Neolithic and Metal Ages. On the other hand, mitochondrial diversity is distributed more homogeneously in agreement with older population events that might be related to the presence of an Italian Refugium during the last glacial period in Europe. |
Keywords: | Genographic Consortium Chromosomes, Human, Y Humans DNA, Mitochondrial Cluster Analysis Genetics, Population Phylogeny Haplotypes Geography Principal Component Analysis Time Factors Italy Female Male Genetic Variation |
Description: | University of Adelaide Genographic Consortium contributers: Christina J. Adler, Alan Cooper, Clio S. I. Der Sarkissian, Wolfgang Haak. |
Rights: | © 2013 Boattini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0065441 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0065441 |
Appears in Collections: | Aurora harvest Earth and Environmental Sciences publications Environment Institute publications |
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hdl_79022.pdf | Published version | 2.13 MB | Adobe PDF | View/Open |
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