Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/79224
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Type: | Journal article |
Title: | Proton pump inhibitors and the risk of pneumonia: A comparison of cohort and self-controlled case series designs |
Author: | Ramsay, E. Pratt, N. Ryan, P. Roughead, E. |
Citation: | BMC Medical Research Methodology, 2013; 13(1):1-7 |
Publisher: | BioMed Central Ltd. |
Issue Date: | 2013 |
ISSN: | 1471-2288 1471-2288 |
Statement of Responsibility: | Emmae N Ramsay, Nicole L Pratt, Philip Ryan and Elizabeth E Roughead |
Abstract: | Background: To compare the results of a new-user cohort study design and the self-controlled case series (SCCS) design using the risk of hospitalisation for pneumonia in those dispensed proton pump inhibitors compared to those unexposed as a case study. Methods: The Australian Government Department of Veterans’ Affairs administrative claims database was used. Exposure to proton pump inhibitors and hospitalisations for pneumonia were identified over a 4 year study period 01 Jul 2007 -30 Jun 2011. The same inclusion and exclusion criteria were applied to both studies, however, the SCCS study included subjects with a least one hospitalisation for pneumonia. Results: There were 105,467 subjects included in the cohort study and 6775 in the SCCS. Both studies showed an increased risk of hospitalisations for pneumonia in the three defined risk periods following initiation of proton pump inhibitors compared to baseline. With the highest risk in the first 1 to 7 days (Cohort RR, 3.24; 95% CI (2.50, 4.19): SCCS: RR, 3.07; 95% CI (2.69, 3.50)). Conclusions: This study has shown that the self-controlled case series method produces similar risk estimates to a new-users cohort study design when applied to the association of proton pump inhibitors and pneumonia. Exposure to a proton pump inhibitor increases the likelihood of being admitted to hospital for pneumonia, with the risk highest in the first week of treatment. |
Keywords: | Humans Pneumonia Hospitalization Risk Cohort Studies Research Design Aged, 80 and over South Australia Female Male Proton Pump Inhibitors |
Rights: | © 2013 Ramsay et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1186/1471-2288-13-82 |
Published version: | http://dx.doi.org/10.1186/1471-2288-13-82 |
Appears in Collections: | Aurora harvest 4 Public Health publications |
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hdl_79224.pdf | Published version | 221.24 kB | Adobe PDF | View/Open |
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