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|Title:||Dyspepsia and irritable bowel syndrome in China: a population-based endoscopy study of prevalence and impact|
|Citation:||Alimentary Pharmacology and Therapeutics, 2010; 32(4):562-572|
|Y. Zhao, D. Zou, R. Wang, X. Ma, X. Yan, X. Man, L. Gao, J. Fang, H. Yan, X. Kang, P. Yin, Y. Hao, Q. Li, J. Dent, J. Sung, K. Halling, B. Wernersson, S. Johansson, and J. He|
|Abstract:||Background: Dyspepsia and irritable bowel syndrome (IBS) are common in Western populations. Aim: To determine the epidemiology of dyspepsia and IBS in China. Methods: A representative sample of 18 000 adults from five regions of China were asked to complete the modified Rome II questionnaire; 20% were asked to complete the 36-item Short Form Health Survey (SF-36). Participants from Shanghai were invited to provide blood samples and undergo oesophagogastroduodenoscopy. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined using a multivariate logistic regression model. Results: The survey was completed by 16 091 individuals (response rate: 89.4%). Overall, 387 participants (2.4%) had dyspepsia and 735 (4.6%) had IBS. All SF-36 dimension scores were at least five points lower in individuals with than without dyspepsia or IBS (P ≤ 0.001). In Shanghai, 1030 (32.7%) of the 3153 respondents agreed to endoscopy; neither dyspepsia nor IBS was found to be associated with reflux oesophagitis, peptic ulcer disease or Helicobacter pylori infection. Conclusions: Prevalence estimates for dyspepsia and IBS in China are lower than in Western populations. In China, dyspepsia or IBS symptoms are generally not associated with underlying organic disease.|
|Keywords:||No keywords specified|
|Rights:||© 2010 Blackwell Publishing Ltd.|
|Appears in Collections:||Medicine publications|
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