Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8798
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Vitamin D receptor genotypes are related to bone size and bone density in men.
Author: Need, A.
Horowitz, M.
Stiliano, A.
Scopacasa, F.
Morris, H.
Chatterton, B.
Citation: European Journal of Clinical Investigation, 1996; 26(9):793-796
Publisher: BLACKWELL SCIENCE LTD
Issue Date: 1996
ISSN: 0014-2972
1365-2362
Abstract: Three restriction fragment length polymorphisms in the vitamin D receptor gene have been associated with a low bone density in twin and female population studies, but no studies have been conducted exclusively in men. We studied 146 normal men aged 20-83 years. Bone density was measured in the spine, hip, whole body and forearm, and the Bsm polymorphism for the vitamin D receptor was detected by the polymerase chain reaction. Men with genotype BB tended to have a lower bone density at all but one site than the other genotypes. In the men < or = 50 years of age bone density in the forearm was 7% lower in the BB than the Bb and bb groups (P = 0.030) but bone mineral content did not differ between the groups. Bone area was greater in the BB genotype at all sites. This was statistically significant in the forearm (P = 0.026). We conclude that BB genotype is associated with lower bone density in men, which may be due to larger bone size rather than reduced bone mass.
Keywords: Humans; Receptors, Calcitriol; Absorptiometry, Photon; Body Constitution; Bone Development; Bone Density; Genotype; Polymorphism, Restriction Fragment Length; Adult; Aged; Aged, 80 and over; Middle Aged; Male
RMID: 0030004983
DOI: 10.1046/j.1365-2362.1996.2080554.x
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.