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https://hdl.handle.net/2440/93583
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Type: | Journal article |
Title: | The effect on human tumor necrosis factor α and interleukin 1β production of diets enriched in n-3 fatty acids from vegetable oil or fish oil |
Other Titles: | The effect on human tumor necrosis factor alpha and interleukin 1beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil |
Author: | Caughey, G.E. Mantzioris, E. Gibson, R.A. Cleland, L.G. James, M.J. |
Citation: | American Journal of Clinical Nutrition, 1996; 63(1):116-122 |
Publisher: | American Society for Clinical Nutrition |
Issue Date: | 1996 |
ISSN: | 0002-9165 1938-3207 |
Statement of Responsibility: | Gillian E Caughey, Evangeline Mantzioris, Robert A Gibson, Leslie G Cleland, and Michael J James |
Abstract: | The effect of a flaxseed oil-based diet on tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta) synthesis was examined in healthy volunteers. Use of flaxseed oil in domestic food preparation for 4 wk inhibited TNF alpha and IL-1 beta production by approximately 30%. Fish-oil supplementation (9 g/d) continued for a further 4 wk; TNF alpha and IL-1 beta synthesis were inhibited by 74% and 80%, respectively. There was a significant inverse exponential relation between TNF alpha or IL-1 beta synthesis and mononuclear cell content of eicosapentaenoic acid (EPA), an n--3 fatty acid derived from ingested EPA (fish oil) or metabolism of ingested alpha-linolenic acid (flaxseed oil). Cytokine production decreased as cellular EPA increased to approximately 1% of total fatty acids. Further increases in EPA content did not result in further decreases in cytokine production. The results indicate that vegetable oils rich in n--3 fatty acids inhibit TNF alpha and IL-1 beta synthesis. |
Keywords: | flaxseed oil monocytes |
Rights: | © 1996 by The American Society for Clinical Nutrition, Inc |
DOI: | 10.1093/ajcn/63.1.116 |
Published version: | http://dx.doi.org/10.1093/ajcn/63.1.116 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 7 |
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