Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/113608
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Type: Journal article
Title: Hydrogen sulphide and phosphine interactions with human skin in vitro: Application to hazardous material incident decision making for skin decontamination
Author: Gaskin, S.
Heath, L.
Pisaniello, D.
Evans, R.
Edwards, J.
Logan, M.
Baxter, C.
Citation: Toxicology and Industrial Health, 2017; 33(4):289-296
Publisher: SAGE Publications
Issue Date: 2017
ISSN: 0748-2337
1477-0393
Statement of
Responsibility: 
Sharyn Gaskin, Linda Heath, Dino Pisaniello, Richard Evans, John W Edwards, Michael Logan and Christina Baxter
Abstract: Accidental or intentional releases of toxic gases can have significant public health consequences and emergency resource demands. Management of exposed individuals during hazardous material incidents should be risk and evidence based, but there are knowledge gaps in relation to dermal absorption of gases and management advice for potentially exposed individuals. Using a modified Organization for Economic Co-operation and Development (OECD) in vitro toxicology protocol with human donor skin, this article reports on two common and odorous chemicals, hydrogen sulphide and phosphine. Results show that undamaged human skin provides a good barrier to hydrogen sulphide (up to 800 ppm) and phosphine (up to 1000 ppm) penetration for up to 30 min exposures, with little variability in the presence of clothing or in elevated temperature and humidity conditions. A practical guideline template for skin decontamination has been developed, and implications of the research for first responders are outlined.
Keywords: Dermal; vapour; emergency response; phosphine; hydrogen sulphide
Rights: © The Author(s) 2016 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav
RMID: 0030045053
DOI: 10.1177/0748233716630646
Appears in Collections:Public Health publications

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